Tail Flick, Acute Pain, Mouse

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
In rodents, the tail flick response to radiant heat is commonly used as a model to detect potentially useful analgesic agents. This assay may be useful to discriminate between centrally acting morphine-like analgesics (active) and non-opioid or peripherally acting anti-inflammatory agents (inactive).
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 8 male ICR mice weighing 23 ± 3 grams (g) are employed. Test substance is administered orally (PO) one hour before the tail flick test. The time (seconds) required to elicit a tail flick response induced by focused radiant heat is measured as the pain threshold. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle and treatment groups. p<0.05 is considered significant. Suggested Testing: n=8/group (study design dependent). Analgesic effects assessed at an initial dose of 30 mg/kg (p.o.). Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
Increase in tail withdrawal time. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle control and treated groups.
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
CNS/Addiction/Pain
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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