PDS >> Efficacy Models >> CNS/Pain

CNS/Pain In vivo Models for Drug Discovery


The central nervous system (CNS) is prone to many diseases and pain-related disorders, especially prevalent during aging. The importance of CNS disorders is indicated by the severity of many of the diseases associated with it, these diseases include depression, epilepsy, psychosis, multiple sclerosis, and many other common, yet difficult-to-treat diseases.

Pharmacology Discovery Services has conducted in vivo testing for CNS and pain disorders for both efficacy and side-effect profiling for over 30 years.  All CNS/Pain in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients.  To meet the needs of your specific CNS/Pain drug discovery project we also have the flexibility and expertise to develop custom in vivo models.

Speak with
an expert

Download our
model list



CNS In Vivo Models

Our experience with CNS models includes both side effect profiling (modified Irwin testing, MTD, locomotor activity and roto-rod coordination) and efficacy models of human CNS disorders.  Some of our validated CNS efficacy models include epilepsy, affective disorders, neuroleptic and multiple sclerosis. 

Pain In Vivo Models

The in vivo pain models we offer include acute, inflammatory and neuropathic pain along with translational models of pain such as osteoarthritis and bone cancer pain.  Additionally, we offer several pain-associated behavioral measurements such as mechanical allodynia, thermal and mechanical hyperalgesia, as well as cold allodynia. 

In Vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.  


CNS/Pain In Vivo Models
Model Name Item Number Species Price/Animal ($USD)
Adenosine A1 Agonism 500300 Rat 220
Adenosine A1 Antagonism 500610 Rat 220
Adrenergic alpha1 Antagonism 501010 Mouse 220
Adrenergic alpha2a Agonism 501500 Rat 220
Adrenergic alpha2a Antagonism 502010 Rat 220
Adrenergic beta1 Antagonism 502500 Mouse 220
Analgesia, Acetic Acid Writhing 503900 Mouse 190
Analgesia, Bone Cancer Pain, MRMT 504500 Rat 570
Analgesia, Carrageenan-Induced Mechanical Allodynia 503940 Rat 325
Analgesia, Complete Freund's Adjuvant-Induced Mechanical Allodynia 503950 Rat 325
Analgesia, Complete Freund's Adjuvant-Induced Thermal Hyperalgesia 503955 Rat 325
Analgesia, Mono Sodium Iodoacetate-Induced Osteoarthritis Pain 503960 Rat 460
Analgesia, Formalin 504000 Mouse 215
Analgesia, Formalin 504010 Rat 280
Analgesia, Phenylquinone (PQ) Writhing 505000 Mouse 190
Analgesia, Post-operative Pain 505700 Rat 400
Analgesia, Tail flick 506020 Mouse 180
Analgesia, Tail flick 506040 Rat 220
Analgesia, Hot Plate 506600 Rat 260
Antipyretic Test 508700 Mouse 200
Anxiety, 5-MeODMT Potentiation 509010 Rat 210
Anxiety, Elevated Plus-Maze 508900 Rat 210
Behavior, Modified Irwin Screen 509600 Rat 380
Behavior, Modified Irwin Screen, Safety non-GLP 509500 Mouse 280
Bleeding Time 510000 Mouse 180
Body Temperature, Safety non-GLP 511000 Rat 220
Bradykinin Potentiation 511300 Rat 260
Catalepsy 516510 Rat 200
Cholinergic Agonism, Central/Peripheral 520010 Rat 220
Clotting Time 522500 Rat 370
Convulsions, Maximal Electroshock 523990 Mouse 185
Convulsions, Maximal Electroshock 524020 Rat 220
Convulsions, Metrazole 525010 Mouse 185
Convulsions, Pro-Electroshock 526000 Mouse 185
Convulsions, Pro-Metrazole 526500 Mouse 185
Depression, Forced Swim Test 527520 Mouse 185
Depression, Forced Swim Test 527540 Rat 280
Depression, Tail Suspension 527400 Mouse 185
Depression, Tetrabenazine Hypothermia 527500 Mouse 185
Emesis, Suncus murinus 530820 Suncus 720
GABAA Agonism/Antagonism 532010 Mouse 185
Gastrointestinal Motility 537920 Mouse 190
Gastrointestinal Motility 537940 Rat 260
Glutamate, Agonism/Antagonism 542010 Mouse 175
Glutamate, Kainate Agonism/Antagonism 543010 Mouse 175
Glutamate, NMDA Agonism/Antagonism 544010 Mouse 175
Glycine, Strychnine-Sensitive, Agonism/Antagonism 545010 Mouse 175
Inflammation, Carrageenan 553510 Mouse 175
Inflammation, Carrageenan 553520 Rat 270
Maximum Tolerated Dose (MTD), Autonomic Signs 560000 Mouse 200
Maximum Tolerated Dose (MTD), Autonomic Signs 561600 Rat 260
Motor Coordination, Roto-Rod 562010 Mouse 185
Motor Coordination, Roto-Rod 562600 Rat 250
Motor Spontaneous Activity, Safety non-GLP 563000 Mouse 220
Motor, Spontaneous Activity 563020 Rat 270
Neuropathic Pain, L5 Spinal Nerve Ligation 504250 Mouse 650
Neuropathic Pain, Bennett Model, Nerve Ligation 504100 Rat 500
Neuropathic Pain, Chung Model 504200 Rat 600
Neuropathic Pain, Paclitaxel-Induced 504400 Rat 400
Neuropathic Pain, Streptozotocin (STZ)-Induced 504600 Rat 450
Potassium Channel [KATP] Agonism/Antagonism 568020 Mice 175
Pruritus (Itch), BAM 8-22-Induced 509870 Mouse 225
Pruritus (Itch), Chloroquine-Induced 509800 Mouse 225
Pruritus (Itch), Compound 48/80-Induced 509820 Mouse 225
Pruritus (Itch), Histamine-Induced 509850 Mouse 225
Pruritus (Itch), Serotonin-Induced 509860 Mouse 225
Pruritus (Itch), SLIGRL-NH2-induced 509840 Mouse 225
Pruritus (Itch), Substance P-induced 509810 Mouse 225
Serotonin (5-Hydroxytryptamine) 5-HT1A Agonism 576810 Rat 220
Serotonin (5-Hydroxytryptamine) 5-HT3 Antagonism 577010 Mouse 175
Serotonin (5-Hydroxytryptamine) 5-HT3 Antagonism 577060 Rat 220
Sleep Time, Hexobabital Potentiation 578010 Mouse 175