The central nervous system (CNS) is prone to many diseases and pain-related disorders, especially prevalent during aging. The importance of CNS disorders is indicated by the severity of many of the diseases associated with them. These diseases include depression, epilepsy, psychosis, multiple sclerosis, and many other common, yet difficult-to-treat diseases.

Pharmacology Discovery Services has conducted in vivo testing for CNS and pain disorders for both efficacy and side-effect profiling for over 50 years. All CNS/Pain in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients. To meet the needs of your specific CNS/Pain drug discovery project, we also have the flexibility and expertise to develop custom in vivo models.

Speak with
an expert

Download
Flyer

Publications

• Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management. Peng Y et al. Journal of medicinal chemistry. 2020 Dec;64(1):890–904. https://doi.org/10.1021/acs.jmedchem.0c01964
• Aquaporin-4 facilitator TGN-073 demonstrates novel analgesic activity. Huber VJ. bioRxiv. 2018 Oct:403311. https://doi.org/10.1101/403311