PDS >> Efficacy Models >> CNS/Pain

CNS/Pain In vivo Models for Drug Discovery


The central nervous system (CNS) is prone to many diseases and pain-related disorders, especially prevalent during aging. The importance of CNS disorders is indicated by the severity of many of the diseases associated with it, these diseases include depression, epilepsy, psychosis, multiple sclerosis, and many other common, yet difficult-to-treat diseases.

Pharmacology Discovery Services has conducted in vivo testing for CNS and pain disorders for both efficacy and side-effect profiling for over 30 years.  All CNS/Pain in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients.  To meet the needs of your specific CNS/Pain drug discovery project we also have the flexibility and expertise to develop custom in vivo models.

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CNS In vivo Models

Our experience with CNS models includes both side effect profiling (modified Irwin testing, MTD, locomotor activity and roto-rod coordination) and efficacy models of human CNS disorders.  Some of our validated CNS efficacy models include epilepsy, affective disorders, neuroleptic and multiple sclerosis. 

Pain In vivo Models

The in vivo pain models we offer include acute, inflammatory and neuropathic pain along with translational models of pain such as osteoarthritis and bone cancer pain.  Additionally, we offer several pain-associated behavioral measurements such as mechanical allodynia, thermal and mechanical hyperalgesia, as well as cold allodynia. 

In vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.  


CNS/Pain In Vivo Models
Model Name Item Number Species
Analgesia, Acetic Acid Writhing 503900 Mouse
Analgesia, Carrageenan-Induced Mechanical Allodynia 503940 Rat
Analgesia, Complete Freund's Adjuvant-Induced Mechanical Allodynia 503950 Rat
Analgesia, Complete Freund's Adjuvant-Induced Thermal Hyperalgesia 503955 Rat
Analgesia, Mono Sodium Iodoacetate-Induced Osteoarthritis Pain 503960 Rat
Analgesia, Formalin 504000 Mouse
Analgesia, Formalin 504010 Rat
Analgesia, Neuropathic pain, Bennett Model, Nerve Ligation 504100 Rat
Analgesia, Neuropathic pain, Chung Model 504200 Rat
Analgesia, Phenylquinone (PQ) Writhing 505000 Mouse
Analgesia, Post-operative Pain 505700 Rat
Analgesia, Tail flick 506020 Mouse
Analgesia, Tail flick 506040 Rat
Analgesia, Hot Plate 506600 Rat
Antipyretic Test 508700 Mouse
Anxiety, 5-MeODMT Potentiation 509010 Rat
Behavior, Scratching, Chloroquine induced 509800 Mouse
Behavior, Scratching, Substance P-induced 509810 Mouse
Behavior, Scratching, Compound 48/80-induced 509820 Mouse
Behavior, Scratching, SLIGRL-NH2-induced 509840 Mouse
Behavior, Scratching, Histamine-induced 509850 Mouse
Behavior, Scratching, Serotonin-induced 509860 Mouse
Bleeding Time 510000 Mouse
Catalepsy 516510 Rat
Clotting Time 522500 Rat
Convulsions, Maximal Electroshock 524020 Rat
Convulsions, Metrazole 525010 Mouse
Convulsions, Pro-Electroshock 526000 Mouse
Convulsions, Pro-Metrazole 526500 Mouse
Depression, Tail Suspension 527400 Mouse
Depression, Tetrabenazine Hypothermia 527500 Mouse
Depression, Despair Swimming 527520 Mouse
Depression, Forced Swim Test, Rat 527540 Rat
Emesis, Suncus murinus 530820 Suncus
GABAA Agonism/Antagonism 532010 Mouse
Glutamate, Agonism/Antagonism 542010 Mouse
Glutamate, Kainate Agonism/Antagonism 543010 Mouse
Glutamate, NMDA Agonism/Antagonism 544010 Mouse
Glycine, Strychnine-Sensitive, Agonism/Antagonism 545010 Mouse
Motor Coordination, Roto-Rod 562010 Mouse
Motor Coordination, Roto-Rod 562600 Rat
Motor Spontaneous Activity, Safety non-GLP 563000 Mouse
Motor, Spontaneous Activity 563020 Rat
Myopia, Form Deprivation Mouse 565050 Mouse
Serotonin (5-Hydroxytryptamine) 5-HT1A Agonism 576810 Rat
Serotonin (5-Hydroxytryptamine) 5-HT3 Antagonism 577010 Mouse
Serotonin (5-Hydroxytryptamine) 5-HT3 Antagonism 577060 Rat
Sleep Time, Hexobabital Potentiation 578010 Mouse