Streptococcus pyogenes (ATCC 14289), Peritonitis Model, LD90-100

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model assesses the efficacy of test articles at protecting against a lethal peritonitis infection. It can be used to evaluate small molecules, vaccines and biologics. Streptococcus pyogenes, group A streptococcus, is a commensal bacterium that can cause skin, soft tissue and throat infections and also life-threatening systemic disease.
SPECIES
Streptococcus pyogenes
ORGANISM
Gram-positive Bacteria
INCUBATION CONDITIONS
Aerobic
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 10 immune competent mice are used.  Each animal is inoculated with an intraperitoneally administered LD90-100 dose of pathogen with 5% mucin.  Test substance and vehicle are administered one hour later. Doses may be administered IV, SC, PO, IM, IP or by IV infusion. Mortality is recorded daily during the following 7 days.  Prevention of mortality in 50 percent or more (>50%) of the animals indicates significant activity.  The Minimum Effective Dose (MED) is defined as the dose that results in survival of 50% (or more) of the test animals.
CRITERIA FOR SIGNIFICANCE
≥ 50% of survival
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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