Streptococcus pneumoniae (ATCC 6301), Lung Infection Model, LD90-100
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DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model assesses the efficacy of test articles for protection against a lethal lung infection. The procedure can be used to evaluate small molecules, vaccines and biologics. Streptococcus pneumoniae is a major cause of common respiratory diseases such as bronchitis and sinusitis) as well as life threatening diseases including pneumonia, and septicemia.
SPECIES
Streptococcus pneumoniae
ORGANISM
Gram-positive Bacteria
INCUBATION CONDITIONS
Aerobic
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 10 mice are used. Animals are anesthetized then inoculated, intranasally or intratracheally, with a lethal (LD90-100) dose of pathogen. Test substance and vehicle are administered one hour after infection. Doses may be administered IV, SC, PO, IM, IP or by IV infusion. Mortality is recorded daily during the following 7 days. Prevention of mortality in 50 percent or more (>50%) of the animals indicates significant activity. The Minimum Effective Dose (MED) is defined as the dose that results in survival of 50% (or more) of the test animals.
CRITERIA FOR SIGNIFICANCE
≥ 50% of survival
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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