Staphylococcus aureus USA300 MRSA (BAA-1556), Dermal Infection Model, CFU Data
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OVERVIEW
DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model evaluates the antimicrobial efficacy of test articles for treatment of superficial skin infections with a community acquired MRSA. USA300 S. aureus is a community-associated epidemic MRSA that causes rapidly progressive and fatal diseases. This MDR strain, originally named FPR 3757, is resistant to mupirocin, quinolones, macrolides and most classes of beta-lactam antibiotics. It is susceptible to fusidic acid and also vancomycin, daptomycin, linezolid, and carbapenems.
SPECIES
Staphylococcus aureus
ORGANISM
Gram-positive Bacteria
INCUBATION CONDITIONS
Aerobic
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 5 immune competent mice are used. The animals are anesthetized, the fur on the back is removed with an electric shaver, and the epidermal layer is disrupted with an abrasive paper. Infection is initiated by placing a droplet containing pathogen suspension on the wound area. Test article is administered at time points after infection. Doses may also be administered topically or by IV, SC, PO, IM, IP or IV infusion. At 24 after the first treatment, animals are humanely euthanized and the skin tissue is aseptically removed. Tissue is homogenized and pathogen counts are determined by plating to agar medium. Pathogen counts from treatment groups are compared to vehicle groups and the significance of an effect is determined.
CRITERIA FOR SIGNIFICANCE
Significant difference is determined at ≥ 2-log or P < 0.05
TURNAROUND TIME
STANDARD
25 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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