Rotarod, Mouse
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DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
The rotarod test is a performance test based on a turning rod with forced motor activity being applied, usually by a rodent. The test measures parameters such as riding time (seconds) or endurance. Some of the functions of the test include evaluating balance, grip strength and motor coordination of the test animals; especially in evaluating the effect of test articles.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test substance is administered orally (PO) to a group of 5 pre-selected male ICR mice weighing 23 ± 3 grams (g) one hour before being placed on a turning rod. Selected animals are those which remain on a rotarod covered covered with roughened tubing of 3.5 cm diameter turning at an accelerating speed from 4 to 36 rpm/min, during a 4 min period. Motor incoordination is then indicated if none or less than 50 percent (<50%) of 5 animals remain on the turning rod. Suggested Testing: n=5/group (study design dependent). Motor incoordination effect assessed at an initial dose of 100 mg/kg. Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
≥50% of tested animals not remain on the rod rotating at from 4 to 36 rpm/min, during a 4 min period.
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
CNS/Addiction/Pain
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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