Pruritus (Itch), Interleukin (IL)-31-Induced

  1. image
  2. image
CONTACT CUSTOMER SERVICE
  ADD TO FAVORITES
  ADD TO PANEL
OVERVIEW
DOCUMENTS/REFERENCES
RELATED SERVICES
RELATED PRODUCTS
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
In vivo pharmacology assays may serve to extend in vitroresults or detect potentially important primary and/or secondary pharmacodynamic activities. Semi-quantitative or quantitative data can be generated on request.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
FUNCTIONAL MODE
Antagonist
TESTING INFORMATION
PROCEDURE SUMMARY
Test substance is administered orally (PO) to groups of 8 male ICR mice weighing 23 ± 3 grams (g) 60 minutes before pruritogen challenge (300 ng/site). The number of scratches is recorded for 40 minutes after pruritogen injection. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle and treatment groups. p<0.05 is considered significant. Suggested Testing: n=8/group (study design dependent). Antipruritic effects were assessed at an initial dose of 30 mg/kg (PO). Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
Reduction of itching counts. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle control and treated groups.
TURNAROUND TIME
STANDARD
30 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
CNS/Addiction/Pain
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei

 

© Copyright 2026, Pharmacology Discovery Services – Privacy Policy | Cookie Notice | Cookie Preferences