Pancreatitis, Caerulein-Induced, Acute
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DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Caerulein-induced pancreatitis in mice is a well-studied model of the gastrointestinal disorders, including acute pancreatitis and chronic pancreatitis. The initiation of this disorder is mediated with activation of a cascade of digestive zymogens that results in acinar cell necrosis and pancreatic edema followed by an inflammatory response. The caerulein-induced pancreatitis is a useful mouse model to examine mechanisms of pathogenesis, therapeutic or prophylactic efficacy.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 6 male ICR mice weighing 22 ± 2 g are used and fasted overnight. Caerulein (100 µg/kg i.p.) is then injected three times at 2 hour intervals and test article is administered by oral gavage (PO) one hour after each injection. Animals are sacrificed 9 hours after the first caerulein injection and serum alpha-amylase concentration from each animal is determined. Additional analyses that can be requested include serum lipase levels, MPO activity, pancreas weight, biomarker analysis (protein and/or mRNA) and histopathology etc. Doses may be administered PO, IV, IP, and SC. Suggested Testing: n=6/group (study design dependent).
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Inflammation/Allergy
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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