Neisseria gonorrhoeae FA1090 (ATCC 700825), Vaginal Infection Model, CFU Data

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This assay evaluates the antimicrobial efficacy of test articles in a mouse vaginal infection model with Neisseria gonorrhoeae (FA1090 ATCC 700825).  The microbial counts in vaginal lavage fluid are measured. Neisseria gonorrhoeae is a Gram-negative bacterium responsible for gonorrhea. Strain ATCC 700825, otherwise known as FA1090, is commonly reported in the literature for mouse pathogenesis studies.
SPECIES
Neisseria gonorrhoeae
ORGANISM
Gram-negative Bacteria
INCUBATION CONDITIONS
Aerobic
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 5 ovariectomize mice are used. Estrogen supplementation is supplied with 17β-estradiol administration. Animals are intravaginally inoculated with pathogen suspension.  Test articles and vehicle are administered 2 hours after inoculation.  Doses may be administered IV, SC, PO, IM, or IP. At time points, animals are humanely euthanized, vaginal lavage is performed and the pathogen burden in lavage fluid is measured.  Pathogen counts from treatment groups are compared to vehicle groups and the signficance of an effect is determined.
CRITERIA FOR SIGNIFICANCE
Significant difference is determined at ≥ 2-log or P < 0.05
TURNAROUND TIME
STANDARD
25 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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