Klebsiella pneumoniae (ATCC 43816), Bacteremia Model (IV Infection), LD90-100
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DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model evaluates the antimicrobial efficacy of test articles for treatment of systemic infections with a susceptible K. pneumoniae strain. It may be used for evaluating small molecules, vaccines and biologics.
SPECIES
Klebsiella pneumoniae
ORGANISM
Mouse
INCUBATION CONDITIONS
Aerobic
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 10 male or female specific-pathogen-free BALB/c mice weighing 18 ± 2 g are used. Each animal is inoculated with an intravenously administered LD90-100 dose (2.5-5.0 x 10^5 CFU/mouse) of Klebsiella pneumoniae (ATCC 43816) suspended in 0.1 mL PBS. Test substance and vehicle are administered at 1 and 13 hour later (BID) or per the client’s specifications. Standard dose routes are IP, PO, IV or SC injection. Mortality is recorded daily during the following 7 days. Prevention of mortality is recorded in percentage and the significance is assessed by Fisher’s exact test.
TURNAROUND TIME
STANDARD
25 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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