Glucose, Blood, Oral Glucose Tolerance Test (OGTT), Mouse

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
The glucose tolerance test is a medical test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood. The test is usually used to test for diabetes, insulin resistance, impaired beta cell function, and sometimes reactive hypoglycaemia and acromegaly, or rarer disorders of carbohydrate metabolism.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 6 male ICR weighing 22 ± 4 g, are fasted overnight (about 16 hours) and test article is administered to test animals 30 minutes before oral glucose (1g/kg) loading. Blood is collected from tail vein and the blood glucose is measured by a Glucometer at -30 (pretreatment), 0 (before glucose loading), 30, 60, 90 and 120 minutes after glucose loading. The area under the curve over 120 min (AUC0-120 min) is determined. In addition, the peak blood glucose is compared at all time-points. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Metabolic Diseases
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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