Gastric Ulcers, Aspirin-Induced
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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Gastric hyperacidity and ulcer are very common disease. Oxygen derived free radicals implication, in the pathogenesis of a wide variety of clinical disorders, caused by physical and chemical factors that lead to gastric ulceration in experimental animals.
ORGANISM
Rat
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test article is administered by oral gavage (PO) to a group of 6 male overnight-fasted Wistar rats weighing 160 ± 10 g 60 minutes before oral gavage with aspirin (150 mg/kg). Four hours later, animals are sacrificed and gastric ulceration is scored for degree of hemorrhage and severity of ulcerative lesions as follows: 0 = no hyperemia or bleeding, 1 = hyperaemia, 2 = slight spot bleeding, 3 = hyperemia plus slight spot bleeding, 4 = hyperemia plus spot bleeding within entire stomach. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Gastroenterology
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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