Gastric Irritation

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DOCUMENTS/REFERENCES
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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Aspirin is the drug of choice when a mild analgesic antipyretic is required. However, Aspirin causes gastric damage and ulcer formation by topical irritant effects and indirect damage via systemic inhibition of cyclooxygenase synthesis and microcirculation injury. Aspirin is commonly used to study the mechanisms of gastric irritation and evaluate the therapeutic efficacy.
ORGANISM
Rat
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test article is administered orally (PO) to a group of 6 male overnight fasted Sprague Dawley (SD) rats weighing 160 ± 10 g. Animals are sacrificed 4 hours later and gastric irritation/ulceration is scored as follows: 0 = no hyperemia or bleeding, 1 = hyperemia, 2 = slight spot bleeding, 3 = hyperemia plus slight spot bleeding, 4 = hyperemia plus spot bleeding within entire stomach. A test article-induced score of 50 percent or more (greater or equal to 50) relative to the aspirin-treated (150 mg/kg, PO) group is considered positive. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.
CRITERIA FOR SIGNIFICANCE
Test article is administered orally (PO) to a group of 6 male overnight fasted Sprague Dawley (SD) rats weighing 160 ± 10 g. Animals are sacrificed 4 hours later and gastric irritation/ulceration is s
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Gastroenterology
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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