Escherichia coli NDM-1 (BAA-2469), Peritonitis Model, LD90-100

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model assesses the antimicrobial efficacy of test articles for protection against a lethal peritoneal infection with a carbapenem resistant NDM-1 producing clinical isolate of Escherichia coli, strain BAA-2469. It may be used for evaluating small molecules, vaccines, biologics, and bacteriophage.
SPECIES
Escherichia coli
STRAIN COMMON NAME
BAA-2469
ORGANISM
Gram-negative Bacteria
INCUBATION CONDITIONS
Aerobic
NOTABLE ANTIBIOTIC RESISTANCE GENE
NDM-1
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
STRAIN SOURCE ID
BAA-2469
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 10 female specific-pathogen-free ICR (CD-1) immunocontent mice are intraperitoneal inoculated with pathogen suspension. Test articles and vehicle are administered per the specification of the study design after inoculation. Doses may be delivered by IV, IV infusion, SC, PO, IM, or IP administration. Mortality is recorded daily during the following 7 days. Prevention of mortality is recorded in percentage and compared to the vehicle treatment group. The significance is assessed with Fisher's exact test. The mean survival time is compared to the vehicle group with Student's t-test or ANOVA.
CRITERIA FOR SIGNIFICANCE
Mortality data is graphed with the Kaplan Meier Method and Significance is assessed with the Fisher's exact test. A significant (p < 0.05) increase in the survival time of the treated animals compared
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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