Escherichia coli (ATCC 700336), Urinary Tract Infection Model, CFU Data

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This assay assesses the antimicrobial efficacy of test articles in an ascending urinary tract infection model.  The microbial counts in kidney and bladder tissue are measured.  This uropathogenic strain, otherwise called J96, is from a human urinary infection. It is a Serotype O4:K6 strain that produces type 1 pili. It is commonly reported in the literature for mouse virulence studies in the urinary tract infection model.
SPECIES
Escherichia coli
ORGANISM
Gram-negative Bacteria
INCUBATION CONDITIONS
Aerobic
SOURCE
STRAIN SOURCE
American Type Culture Collection (ATCC)
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 5 to 8 female mice are used.  Infection is established by transurethral inoculation of an E. coli suscpension into the bladder using a urinary catheter. Test articles are administered starting four days after infection. Doses may be administered IV, SC, PO, IM, IP or by IV infusion. Animals are humanely euthanized at 24 hr after the last dose then microbial counts in bladder and kidney tissue are enumerated.
TURNAROUND TIME
STANDARD
40 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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