Diabetes, Type II, Obese Zucker Diabetic Fatty (ZDF) Rat

ITEM 541700

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BIOLOGICAL INFORMATION

BACKGROUND INFORMATION

Type 2 diabetes (T2D) is a metabolic disorder characterized by high blood glucose due to insulin resistance and insulin deficiency. The Zucker fatty (ZDF) rat is most widely used for study of T2D associated with obesity.

ORGANISM

Rat

ASSAY INFORMATION

ASSAY TYPE

In Vivo

TESTING INFORMATION

PROCEDURE SUMMARY

Groups of 6 obese Zucker diabetic fatty rats (ZDF/Gmi, fa/fa) 12 ± 1 weeks of age are used. After pre-treatment blood collection, test animals receive treatment of vehicle and/or test article by oral gavage (PO) once daily for a total of 7 consecutive days. All animals are allowed free access to normal laboratory chow and water. Blood samples are collected again 90 minutes after the last dosing for serum glucose and insulin determination. Serum glucose and insulin levels are measured by automated biochemical analyzer TBA-120FR and ELISA (rat insulin assay kit) and percent change is determined. Serum glucose and insulin percentage of post-treatment relative to pre-treatment group values obtained on the seventh day are calculated. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.

CRITERIA FOR SIGNIFICANCE

p<0.05 compared to vehicle control is considered significant activity

TURNAROUND TIME

STANDARD

40 Days

CLINICAL RELEVANCE

THERAPEUTIC AREA

Metabolic Diseases

ADDITIONAL INFORMATION

BRAND

PDS

TESTING LOCATION

Taiwan - Taipei

OTHER INFORMATION

We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.