Diabetes, Type II, db/db Mouse

  1. image
CONTACT CUSTOMER SERVICE
  ADD TO FAVORITES
  ADD TO PANEL
OVERVIEW
DOCUMENTS/REFERENCES
RELATED SERVICES
RELATED PRODUCTS
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
db/db mouse is a noninsulin-dependent diabetes mellitus (NIDDM) model animal that shows similar symptoms of human's obesity diabetes. db/db mice have genetically determined obesity and such diabetic syndromes as hyperglycemia, hyperinsulinemia, glucosuria, and severe insulin resistance. This study is to investigate the antidiabetic effect on NIDDM model animals, db/db mice.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test article is administered by oral gavage (PO) once daily for three consecutive days to groups of 6 non-insulin dependent diabetic mellitus (NIDDM) male mice (C57BLKS/J Iar- +Leprᵈᵇ/+Leprᵈᵇ) weighing 50 ± 10 g (10 to 15 weeks old; serum glucose = 500 ± 50 mg/dl, serum insulin = 13.0 ± 2.0 ng/ml). All animals are allowed free access to normal laboratory chow and water. Serum glucose and insulin levels are determined by automated biochemical analyzer TBA-120FR and ELISA (mouse insulin assay kit) before (pre-treatment) and 90 minutes after the last vehicle and/or test article administration (post-treatment) and percent change is determined. Serum glucose and insulin percentage of post-treatment relative to pre-treatment group values obtained on the third day are calculated. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
40 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Metabolic Diseases
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

© Copyright 2026, Pharmacology Discovery Services – Privacy Policy | Cookie Notice | Cookie Preferences