Depression, Tetrabenazine Hypothermia
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OVERVIEW
DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
The TBZ-induced hypothermia test is one of rodent models for evaluating antidepressant-like activity in mice. The test is based on the fact that animals injected with TBZ, will show the sign of hypothermia. Various antidepressant medications reverse the hypothermic response.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test substance is administered orally (PO) to a group of 5 ICR male mice weighing 23 ± 3 grams (g) 30 minutes after injection of tetrabenazine (TBZ, 85 mg/kg IP). Body temperature is recorded at 0 minute (immediately before TBZ) and 60 minutes later. Inhibition of tetrabenazine-induced hypothermic response by 50 percent or more (>50%) is considered significant and may indicate antidepressant activity. Suggested Testing: n=8/group (study design dependent). Antidepressant activity assessed at an initial dose of 30 mg/kg. Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
Reduction ≥ 50% of TBZ (85 mg/kg IP)-induced hypothermia.
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
CNS/Addiction/Pain
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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