Cholesterol, Normal Serum (Total, HDL, LDL, TG), Mouse
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DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Cholesterol is a lipid needed by the body for many important functions. High serum cholesterol, however, together with other fatty materials (e.g., high levels of LDL and/or low levels of HDL and/or high levels of triglycerides) can result in atherosclerotic plaque with increased risk of developing heart disease and stroke. This animal model is used to evaluate the effects of test article on basal serum lipid levels in mice.
ORGANISM
Mouse
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test article is administered by oral gavage (PO) to a group of 6 male ICR mice weighing 22 ± 2 g. After 24 hours and overnight fasting, serum obtained from each animal is assayed for total cholesterol (T-CHO), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) by automated biochemical analyzer TBA-120FR. Additional analyses that can be requested include biomarkers (protein and/or mRNA) and histopathology etc. Suggested Testing: n=6/group (study design dependent). Doses may be administered PO, IV, IP and SC.
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Metabolic Diseases
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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