Chemotherapy-Induced Neuropathic Pain, Paclitaxel
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OVERVIEW
DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Chemotherapy-induced peripheral neuropathy is one of the most serious complications associated with anticancer drugs. It is an important cause of pain during cancer treatment and is a common pain in the cancer survivor. The presence of chemotherapy-induced pain is noted as hyperalgesia (increased response to noxious stimuli) or allodynia (nociceptive response to normally innocuous stimuli). In the model described below, sharp withdrawal of the hind paw to light mechanical stimuli indicates the presence of allodynia.
ORGANISM
Rat
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 10 male Sprague-Dawley (SD) rats weighing 240 ± 20 grams (g) are employed. Allodynia is induced by intraperitoneal (IP) injections of Paclitaxel (Taxol, 2 mg/kg) every other days with a total of four doses (Days 1, 3, 5, and 7). Rats are preselected (clear presence of allodynia) for experimentation only if the nociceptive response 14 days after Paclitaxel injection (pre-treatment) is reduced by 10 g of force relative to the response of the individual paw before Paclitaxel challenge. Test substance and vehicle are administered orally (PO) to groups of 10 animals one hour before the level of allodynia is again determined (post-treatment). One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle and treatment groups. Activity is considered at p<0.05. Suggested Testing: n=10/group (study design dependent). Analgesic activity assessed at an initial dose of 100 mg/kg. Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
Reduction of Paclitaxel-induced allodynia. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle control and treated groups.
TURNAROUND TIME
STANDARD
60 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Oncology/Immuno-Oncology
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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