Acinetobacter baumannii ADC-25 OXA-66 (CDC & FDA AR Isolate Bank #0280), Lung Infection Model, CFU Data

  1. image
CONTACT CUSTOMER SERVICE
  ADD TO FAVORITES
  ADD TO PANEL
OVERVIEW
DOCUMENTS/REFERENCES
RELATED SERVICES
RELATED PRODUCTS
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
This model assesses the antimicrobial efficacy of test articles in a lung infection model with carbapenem resistant A. baumannii. Microbial counts in the lung tissue are measured. This multiple-drug resistant A. baumannii strain produces aph(3')-Ic, ADC-25, aac(3)-Ia, OXA-66, strA, strB, sul1 and TEM-1D. It is resistant to aminoglycosides and quinolones. It is susceptible to carbapenem, colistin and tigecycline. The FDA-CDC Antimicrobial Resistance Isolate Bank supplied this strain.
ORGANISM
Gram-negative Bacteria
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 5 neutropenic mice are used. Animals are inoculated intranasally with pathogen suspension then test articles or vehicle are administered at time points after inoculation. Doses may be administered IV, SC, PO, IM, IP or by IV infusion. At 24 after the first treatment, animals are humanely euthanized and tissue is aseptically removed.  Tissue is homogenized and pathogen counts are determined by plating to agar medium.  Pathogen counts from treatment groups are compared to vehicle groups and the significance of an effect is determined.
CRITERIA FOR SIGNIFICANCE
Significant difference is determined at ≥ 2-log or P < 0.05
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Infectious Disease
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

© Copyright 2026, Pharmacology Discovery Services – Privacy Policy | Cookie Notice | Cookie Preferences