Solubility Test, HPLC-UV/VIS Method
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OVERVIEW
DOCUMENTS/REFERENCES
BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Solubility tests are important for drug development. The insolubility of test articles may have lower absorption and plasma exposure and will lead to less efficacy. In addition, the compound with the worst solubility may cause deaths when administered, particularly via the intravenous (IV) route. The solubility test can provide a platform to test the solubility of the test articles from various aqueous buffers.
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
The test compound is dissolved in seven different formulation buffers at 200 µg/mL concentration. The samples are incubated for 24 hours at room temperature and then quantified the with HPLC-UV/VIS method.
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Other
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2016). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.
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