Respiration, Blood Gases

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
In vivo pharmacology assays may serve to extend in vitro results or detect potentially important primary and/or secondary pharmacodynamic activities. Semi-quantitative or quantitative data can be generated on request.
ORGANISM
Rat
ASSAY INFORMATION
ASSAY TYPE
In Vivo
TESTING INFORMATION
PROCEDURE SUMMARY
Test substance is administered subcutaneously (SC) to groups of 5 Sprague-Dawley (SD) male rats weighing 240 ± 20 grams (g). Before (0 minute) and 40 minutes after test substance administration, a 0.3 mL sample of blood is withdrawn from a pre-cannulated carotid artery and immediately injected (less than 20 seconds) into a cassette of the blood gas analyzer to determine its pH, pcarbon dioxide and pO2. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle and treatment groups. Activity is considered at p<0.05. Suggested Testing: n=5/group (study design dependent). Suggested Testing: n=5/group (study design dependent). Effects on blood gases assessed at an initial dose of 30 mg/kg. Dosing volume at 10 mL/kg.
CRITERIA FOR SIGNIFICANCE
Changes in blood gas. One-way ANOVA followed by Dunnett's test is applied for comparison between vehicle control and treated groups.
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Pulmonology
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei
OTHER INFORMATION
We will readily accommodate client-specified alterations. These studies are performed at our AAALAC accredited BSL-2 laboratory in Taipei, Taiwan. All aspects of this work are performed in general accordance with the Guide for the Care and Use of laboratory animals (National Academy Press, Washington, DC, 2011). The study protocol was approved by the Pharmacology Discovery Services IACUC and is performed with the oversight of veterinarians to assure the humane treatment of laboratory animals.

 

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