Inflammatory Bowel Disease (IBD), DSS-Induced Colitis, Rat

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BIOLOGICAL INFORMATION
BACKGROUND INFORMATION
Human inflammatory bowel disease (IBD) is a chronic inflammatory condition comprise of two major disorders, Crohn's disease and ulcerative colitis. Dextran Sulfate Sodium (DSS)-induced IBD is a chemically-induced model using DSS in the drinking water that induces ulcerative colitis-like inflammation. The fundamental symptoms of IBD are abdominal pain, bloody diarrhea and body weight loss. DSS-induced IBD is commonly used to study the mechanisms of gastrointestinal inflammation and evaluate the therapeutic efficacy.
ORGANISM
Rat
ASSAY INFORMATION
ASSAY TYPE
In Vivo
FUNCTIONAL MODE
Antagonist
TESTING INFORMATION
PROCEDURE SUMMARY
Groups of 6 male Wistar rats weighing 100 ± 10 g are used. 5% Dextran Sulfate Sodium (DSS), molecular weight 36,000-50,000 Da is given in autoclaved drinking water for 3 days, and then changed to normal drinking water for the following 5 days in the study. The rats in sham group are given drinking water only. Test article, vehicle (10 mL/kg, PO) and the standard, Mesalazine (300 mg/kg, PO) are administered from Day 4 once daily for 4 consecutive days. During the experiment, body weight, fecal occult blood and stool consistency will be recorded daily from Day 4 to Day 8. On Day 8, the rats are euthanized by CO₂ asphyxiation and colon length is record and weighed. Additional analyses that can be requested include biomarkers (protein and/or mRNA), and histopathology etc.
CRITERIA FOR SIGNIFICANCE
p<0.05 compared to vehicle control is considered significant activity
TURNAROUND TIME
STANDARD
20 Days
CLINICAL RELEVANCE
THERAPEUTIC AREA
Inflammation/Allergy
ADDITIONAL INFORMATION
BRAND
PDS
TESTING LOCATION
Taiwan - Taipei

 

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