Efficacy Models >> Oncology >> In vivo

In vivo Oncology Drug Discovery Services

 

Cancer is among the leading causes of death worldwide, it's estimated that more than one in three people will develop cancer in their lifetime.  The fight against cancer includes a variety of therapeutic approaches that includes both small molecule, large molecules and combination therapies.   

Pharmacology Discovery Services has conducted in vivo pharmacology studies for both side-effect profiling and efficacy for over 30 years.  We have a portfolio of both xenograft and syngeneic models that our clients may use to assess the in vivo efficacy of their small molecule or large molecule Oncology drug discovery test agents.  We can meet a variety of study endpoints to generate the high-quality, reproducible data your projects require.  All experimental models are tested in a dose-dependent manner with approved benchmark positive controls.  To meet the needs of your specific Oncology drug discovery project we also have the flexibility and expertise to develop custom in vivo models. 


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Xenograft Models

Our human tumor xenograft model portfolio includes cancer cell lines from the following tissues: brain, breast, central nervous system, colon, kidney, hematologic, liver, lung, ovary, pancreas, prostate, skin and stomach.  Standard efficacy study endpoints, such as Tumor Growth Inhibition, Tumor Growth Delay and Survival are available for all subcutaneous, disseminated and orthotopic xenograft models.

Syngeneic Models

To enable the study of Immuno-Oncology drug candidates, syngeneic models are available.  Standard efficacy study endpoints, such as Tumor Growth Inhibition, Tumor Growth Delay and Survival are available for our syngeneic models.  Our flow cytometry capabilities enable clients to identify and sort immune cell populations of interest and scrutinize the complex immunological mechanisms in play in any given in vivo experiment.  All syngeneic models are characterized for immune checkpoint inhibitor response and baseline immune cell subpopulations within the tumor.

Custom Model Development

Our experienced scientific team is able to generate custom in vivo models to meet the in vivo pharmacology requirements of our clients.  We may use client provided cells or any of the over 300 cancer cell lines from the OncoPanel™ Cell-Based Profiling Service provided by our Partner Lab, Eurofins Pharma Discovery Services.  Custom model development can be completed in as little as three months.

In vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.  

Oncology  In Vivo Models
Model Name Item Number Species
Analgesia, Neuropathic pain, Paclitaxel Induced 504400 Rat
Analgesia, Bone Cancer Pain, MRMT 504500 Rat
Syngeneic, Breast, 4T1  578590 Mouse
Syngeneic, Breast, Orthotopic, Metastasis, 4T1  578591 Mouse
Syngeneic, Colon, CT26.WT 578600 Mouse
Syngeneic, Kidney, Renca  578630 Mouse
Syngeneic, Leukemia, L1210  578650 Mouse
Syngeneic, Lung, KLN 205  578680 Mouse
Syngeneic, Lung, LL/2  578700 Mouse
Syngeneic, Melanoma, B16-F0  578800 Mouse
Syngeneic, Melanoma, Metastasis B16-F0  578850 Mouse
Syngeneic, Melanoma, B16-F10  578810 Mouse
Syngeneic, Sarcoma, A20  578900 Mouse
Xenograft, Brain, U87-MG 579500 Mouse
Xenograft, Brain, HCC-1428  579800 Mouse
Xenograft, Breast, MCF-7 580000 Mouse
Xenograft, Breast, MDA-MB-231  580020 Mouse
Xenograft, Colon, HCT-116  580090 Mouse
Xenograft, Colon, HT-29  580100 Mouse
Xenograft, Colon, SW-480  580150 Mouse
Xenograft, Gastric, NCI-N87  582400 Mouse
Xenograft, Kidney, A-498 580400 Mouse
Xenograft, Leukemia, HL-60 580600 Mouse
Xenograft, Leukemia, MV-4-11 580650 Mouse
Xenograft, Leukemia, THP-1 580680 Mouse
Xenograft, Liver, HEP 3B 580700 Mouse
Xenograft, Liver, PLC-5 580730 Mouse
Xenograft, Lung, A549 580900 Mouse
Xenograft, Lung, NCI-H460  580950 Mouse
Xenograft, Lung, NCI-H526  580960 Mouse
Xenograft, Lymphoma, U937 581000 Mouse
Xenograft, Neuroepithelioma, SK-N-MC 581100 Mouse
Xenograft, Ovary, OVCAR-3 581330 Mouse
Xenograft, Ovary, SK-OV-3 581300 Mouse
Xenograft, Pancreas, BX-PC3 581520 Mouse
Xenograft, Pancreas, MIA PaCa-2 581500 Mouse
Xenograft, Pancreas, PANC-1 581540 Mouse
Xenograft, Prostate, 22Rv1 581920 Mouse
Xenograft, Prostate, LNCaP-clone-FGC 581950 Mouse
Xenograft, Prostate, PC-3 581900 Mouse
Xenograft, Skin, A-431 582000 Mouse
Vascular Permeability (Miles Assay), VEGF 594500 Guinea pig