PDS >> Efficacy Models >> Metabolic / Endocrine

Metabolic / Endocrine In vivo models for Drug Discovery

 

With today's high caloric diets and sedimentary life style, increased attention has been focused on remedying associated metabolic disorders, namely obesity and diabetes.  In early stages, these issues manifest in metabolic syndrome, a complex disease which is characterized by obesity, insulin resistance, pre-diabetic fasting glucose levels, fatty liver, and low HDL cholesterol levels. Left untreated, metabolic disorders can greatly increase the risk of stroke, type II diabetes, and cardiovascular disease.

Pharmacology Discovery Services has conducted in vivo testing for both side-effect profiling and efficacy for Metabolic and Endocrine disease for over 30 years.  The in vivo models we offer include Type I (induction by streptotozocin) and Type II diabetes models. The Type I models allow examination of agents acting on insulin-independent pathways while the Type II models are conventional wildtype or genetic variants (db/db, ob/ob or ZDF) used with or without modified test diets to explore the impact of pharmacological agents on glucose metabolism and/or obesity.  We also offer a panel of chronic kidney disease models, as well as models of acute and chronic hepatic injury.  

All in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients.  To meet the needs of your specific Metabolic/Endocrine drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Validated Metabolic/Endocrine In vivo Models

In order to help you advance your drug candidate(s) we offer a number of relevant models that include:

  • Androgen / estrogen function
  • Cholesterol
  • Food intake
  • Hepatic injury and toxicity
  • Hematopoiesis and thrombosis
  • Obesity (glucose tolerance and insulin levels)
  • Renal function and injury
  • Type I and Type II diabetes

We are able to expertly provide outcome measure of glucose tolerance or insulin tolerance test, as well as plasma lipid profile and measurements of serum insulin, glucagon, leptin, adiponectin, free fatty acid, cytokines, and other relevant biomarkers.

In vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies. 

Metabolic / Endocrine Models
Model Name Item Number Species
Androgen Agonism 507000 Rat
Androgen Antagonism 507500 Rat
Blood Chemistry, Serum 547550 Mouse
Cholesterol, Normal Serum (Total, HDL, LDL, TG), Mouse 518000 Mouse
Cholesterol, Normal Serum (Total, HDL, LDL, TG) Subacute, Mouse 518010 Mouse
Cholesterol, Serum (Total, HDL, LDL, TG) Diet- Induced Guinea Pig 518030 Guinea pig
Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced Hamster 518050 Hamster
Cholesterol, Serum (Total,HDL,LDL,Total/HDL Ratio), Diet-Induced 518510 Mouse
Cholinergic Agonism, Central/Peripheral 520010 Rat
Estrogen Agonism 531000 Mouse
Estrogen Antagonism 531500 Mouse
Food Intake 531700 Mouse
Food Intake 531900 Rat
Glucose, Serum, Fasted 539000 Mouse
Glucose, Serum, Glucose-Loaded 540000 Mouse
Glucose, Serum, Glucose-Loaded 540010 Rat
Glucose, Blood, OGTT Mice 540100 Mouse
Glucose, Blood, OGTT Rat 540110 Rat
Glucose, Serum, Streptozotocin 541000 Mouse
Glucose, Serum, Streptozotocin, Rat 541010 Rat
Glucose, Serum, Starch-Loaded 541500 Mouse
Glucose and Insulin, Serum, KK-AY Mouse 541620 Mouse
Glucose and Insulin, Serum, db/db mouse 541630 Mouse
Glucose and Insulin, Serum, Obese Zucker Diabetic Fatty Rats 541700 Rat
Hematopoiesis, Anemia, Carboplatin-induced Mouse 547300 Mouse
Hematopoiesis, Anemia, Phlebotomized Mouse 547400 Mouse
Hematologiy, Blood Examination (HCT, HGB, PLT, RBC, WBC) 547510 Mouse
Immune, Delayed Type Hypersensitivity induced by SRBC 549500 Mouse
Platelet Activating Factor (PAF) Antagonism 567000 Mouse
Potassium Channel [KATP] Agonism/Antagonism 568020 Mouse
Thrombosis, Abdominal Aorta, Ferric Chloride-Induced 578400 Rat
Thrombosis, Vena Cava, Thromboplastin-Induced 578570 Rat