Metabolic / Endocrine In vivo models for Drug Discovery
With today's high caloric diets and sedimentary life style, increased attention has been focused on remedying associated metabolic disorders, namely obesity and diabetes. In early stages, these issues manifest in metabolic syndrome, a complex disease which is characterized by obesity, insulin resistance, pre-diabetic fasting glucose levels, fatty liver, and low HDL cholesterol levels. Left untreated, metabolic disorders can greatly increase the risk of stroke, type II diabetes, and cardiovascular disease.
Pharmacology Discovery Services has conducted in vivo testing for both side-effect profiling and efficacy for Metabolic and Endocrine disease for over 30 years. The in vivo models we offer include Type I (induction by streptotozocin) and Type II diabetes models. The Type I models allow examination of agents acting on insulin-independent pathways while the Type II models are conventional wildtype or genetic variants (db/db, ob/ob or ZDF) used with or without modified test diets to explore the impact of pharmacological agents on glucose metabolism and/or obesity. We also offer a panel of chronic kidney disease models, as well as models of acute and chronic hepatic injury.
All in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients. To meet the needs of your specific Metabolic/Endocrine drug discovery project we also have the flexibility and expertise to develop custom in vivo models.
Validated Metabolic/Endocrine In vivo Models
In order to help you advance your drug candidate(s) we offer a number of relevant models that include:
- Androgen / estrogen function
- Food intake
- Hepatic injury and toxicity
- Hematopoiesis and thrombosis
- Obesity (glucose tolerance and insulin levels)
- Renal function and injury
- Type I and Type II diabetes
We are able to expertly provide outcome measure of glucose tolerance or insulin tolerance test, as well as plasma lipid profile and measurements of serum insulin, glucagon, leptin, adiponectin, free fatty acid, cytokines, and other relevant biomarkers.
In vivo Pharmacology Expertise
Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients. This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines. They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible. Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.
|Metabolic / Endocrine Models|
|Model Name||Item Number||Species|
|Blood Chemistry, Serum||547550||Mouse|
|Cholesterol, Normal Serum (Total, HDL, LDL, TG)||518000||Mouse|
|Cholesterol, Serum (Total, HDL, LDL, TG) Diet- Induced||518030||Guinea pig|
|Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced||518050||Hamster|
|Cholesterol, Serum (Total,HDL,LDL,Total/HDL Ratio), Diet-Induced||518510||Mouse|
|Cholinergic Agonism, Central/Peripheral||520010||Rat|
|Glucose, Serum, Fasted||539000||Mouse|
|Glucose, Blood, OGTT||540100||Mouse|
|Glucose, Blood, OGTT||540110||Rat|
|Glucose, Serum, Streptozotocin||541000||Mouse|
|Glucose, Serum, Streptozotocin||541010||Rat|
|Glucose, Serum, Starch-Loaded||541500||Mouse|
|Glucose and Insulin, Serum, KK-AY Mouse||541620||Mouse|
|Glucose and Insulin, Serum, db/db Mouse||541630||Mouse|
|Glucose and Insulin, Serum, Obese Zucker Diabetic Fatty Rats||541700||Rat|
|Hematopoiesis, Anemia, Carboplatin-induced Mouse||547300||Mouse|
|Hematologiy, Blood Examination (HCT, HGB, PLT, RBC, WBC)||547510||Mouse|
|Potassium Channel [KATP] Agonism/Antagonism||568020||Mouse|
|Thrombosis, Abdominal Aorta, Ferric Chloride-Induced||578400||Rat|
|Thrombosis, Vena Cava, Thromboplastin-Induced||578570||Rat|