PDS >> Efficacy Models >> Metabolic / Endocrine

Metabolic / Endocrine In vivo models for Drug Discovery


With today's high caloric diets and sedimentary life style, increased attention has been focused on remedying associated metabolic disorders, namely obesity and diabetes.  In early stages, these issues manifest in metabolic syndrome, a complex disease which is characterized by obesity, insulin resistance, pre-diabetic fasting glucose levels, fatty liver, and low HDL cholesterol levels. Left untreated, metabolic disorders can greatly increase the risk of stroke, type II diabetes, and cardiovascular disease.

Pharmacology Discovery Services has conducted in vivo testing for both side-effect profiling and efficacy for Metabolic and Endocrine disease for over 30 years.  The in vivo models we offer include Type I (induction by streptotozocin) and Type II diabetes models. The Type I models allow examination of agents acting on insulin-independent pathways while the Type II models are conventional wildtype or genetic variants (db/db, ob/ob or ZDF) used with or without modified test diets to explore the impact of pharmacological agents on glucose metabolism and/or obesity.  We also offer a panel of chronic kidney disease models, as well as models of acute and chronic hepatic injury.  

All in vivo models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients.  To meet the needs of your specific Metabolic/Endocrine drug discovery project we also have the flexibility and expertise to develop custom in vivo models.

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Validated Metabolic/Endocrine In Vivo Models

In order to help you advance your drug candidate(s) we offer a number of relevant models that include:

  • Androgen / estrogen function
  • Cholesterol
  • Food intake
  • Hepatic injury and toxicity
  • Hematopoiesis and thrombosis
  • Obesity (glucose tolerance and insulin levels)
  • Renal function and injury
  • Type I and Type II diabetes

We are able to expertly provide outcome measure of glucose tolerance or insulin tolerance test, as well as plasma lipid profile and measurements of serum insulin, glucagon, leptin, adiponectin, free fatty acid, cytokines, and other relevant biomarkers.

In Vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies. 

Metabolic / Endocrine Models
Model Name Item Number Species Price/Animal ($USD)
Androgen Agonism 507000 Rat 280
Androgen Antagonism 507500 Rat 280
Cholesterol, Normal Serum (Total, HDL, LDL, TG) 518000 Mouse 210
Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced 518030 Guinea Pig 500
Cholesterol, Serum (Total, HDL, LDL, TG) Diet-Induced 518050 Hamster 500
Cholesterol, Serum (Total, HDL, LDL, Total & HDL Ratio) Diet-Induced 518510 Mouse 320
Cholinergic Agonism, Central/Peripheral 520010 Mouse 220
Diabetes, Type I, Streptozotocin-Induced 541000 Mouse 225
Diabetes, Type I, Streptozotocin-Induced 541010 Rat 275
Diabetes, Type II, db/db Mouse 541630 Mouse 495
Diabetes, Type II, KK-AY Mouse 541620 Mouse 495
Diabetes, Type II, Obese Zucker Diabetic Fatty (ZDF) Rats 541700 Rat Inquire
Estrogen Agonism 531000 Mouse 225
Estrogen Antagonism 531500 Mouse 225
Food Intake 531700 Mouse 200
Food Intake 531900 Rat 240
Glucose, Blood, Oral Glucose Tolerance Test (OGTT) 540100 Mouse 240
Glucose, Blood, Oral Glucose Tolerance Test (OGTT) 540110 Rat 280
Glucose, Serum, Fasted 539000 Mouse 175
Glucose, Serum, Starch-Loaded 541500 Mouse 175
Hematology, Blood Cell Examination (HCT, HGB, PLT, RBC, WBC) 547510 Mouse 180
Hematology, Blood Chemistry, Serum 547550 Mouse 360
Hematopoiesis, Anemia, Carboplatin-Induced 547300 Mouse 290
Hepatic Injury, Acetaminophen (APAP)-Induced 546040 Mouse 190
Hepatic Injury, Concanavalin A-Induced 546030 Mouse 190
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCl4)-Induced 546060 Rat 560
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCI4) with Phenobarbial-Induced 546050 Rat 560
Hepatic Injury, Nonalcoholic Steatohepatitis (NASH), MCD Diet-Induced 546080 Mouse 350
Hepatotoxicity 546110 Mouse 180
Pancreatitis, Acute, Caerulein-Induced 566000 Mouse 230
Potassium Channel [KATP] Agonism/Antagonism 568020 Mouse 175
Wound Healing, Skin 595000 Mouse 265
Wound Healing, Skin, db/db Mouse 595020 Mouse 640