PDS >> Efficacy Models >> Inflammation / Allergy

Inflammation/Allergy In vivo Models for Drug Discovery

 

Pharmacology Discovery Services has over 30 years of experience in developing, and conducting studies with, a diverse set of in vivo models for inflammatory diseases.  These models range from basic models of immune modulation, restoration, suppression and stimulation to specific models of inflammation-induced organ damage.  

Our ability to deliver multi-faceted outcome studies means that you will receive the data that is most appropriate for your drug discovery program.  All experimental models are tested in a dose-dependent manner with approved benchmark positive controls.  We routinely measure relevant biomarkers (e.g., cytokines), physiologic outcomes, like airway hyper responsiveness and swelling.  We also can provide more complex behavioral outcome measures such as scratching or mechanical allodynia or histopathology.    To meet the needs of your specific Inflammation/Allergy drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Validated Inflammation/Allergy In Vivo Models

  • Allergic/irritant contact or atopic dermatitis
  • Allergic reaction
  • Collagen (CIA), mAb (CAIA) or adjuvant (AIA) induced arthritis
  • Colitis
  • Models of immune modulation: restoration, suppression or stimulation
  • Psoriasis
  • Pulmonary Inflammation
  • Septic shock (LPS-induced or cecal ligation and puncture)
  • Wound healing
  • Organ specific models of pancreatitis and pulmonary, hepatic or renal fibrosis

In Vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.

Publications

Inflammation / Allergy Models
Model Name Item Number Species Price/Animal ($USD)
Allergy, Passive Cutaneous Anaphylaxis 503000 Rat 275
Analgesia, Carrageenan-Induced Mechanical Allodynia 503940 Rat 325
Analgesia, Complete Freund's Adjuvant-Induced Mechanical Allodynia 503950 Rat 325
Analgesia, Complete Freund's Adjuvant-Induced Thermal Hyperalgesia 503955 Rat 325
Analgesia, Formalin 504000 Mouse 215
Analgesia, Formalin 504010 Rat 280
Analgesia, Mono Sodium Iodoacetate-Induced Osteoarthritis 503960 Rat 460
Arthritis, Adjuvant-Induced (AIA) 553010 Rat 550
Arthritis, Collagen mAb-Induced (CAIA) 553600 Mouse 685
Arthritis, Collagen-Induced (CIA) 553700 Rat 550
Asthma, Airway Hyperresponsiveness (AHR), Ovalbumin-Induced 568050 Mouse 570
Cough, Capsaicin-Induced 508850 Guinea pig 420
Cough, Citric Acid-Induced 508800 Guinea pig 450
Dermatitis, Atopic, DNCB-Induced 555700 Mouse 950
Dermatitis, Contact, Arachidonic Acid-Induced 554010 Mouse 175
Dermatitis, Contact, Capsaicin-Induced 554310 Mouse 175
Dermatitis, Contact, Croton Oil-Induced 554510 Mouse 175
Dermatitis, Contact, Oxazolone-Induced 555510 Mouse 265
Dermatitis, Contact, Phorbol Ester-Induced 555010 Mouse 175
Fibrosis, Lung, Bleomycin-Induced 568070 Mouse 365
Gastric Irritation 535020 Rat 220
Gastric Ulcers, Aspirin-Induced 535900 Rat 220
Gastric Ulcers, Ethanol-Induced 536000 Rat 220
Gout, Hyperuricemia, Potassium Oxonate-Induced 546600 Rat 275
Hematopoiesis, Anemia, Carboplatin-Induced 547300 Mouse 290
Hepatic Injury, Acetaminophen (APAP)-Induced 546040 Mouse 190
Hepatic Injury, Concanavalin A-Induced 546030 Mouse 190
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCl4)-Induced 546060 Rat 560
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCI4) with Phenobarbial-Induced 546050 Rat 560
Hepatic Injury, Nonalcoholic Steatohepatitis (NASH), MCD Diet-Induced 546080 Mouse 350
Hepatotoxicity 546110 Mouse 175
Histamine H1 Antagonism 547000 Rat 260
Immune Restoration, Hematopoiesis 550600 Mouse 290
Inflammation, Carrageenan-Induced 553510 Mouse 175
Inflammation, Carrageenan-Induced 553520 Rat 270
Inflammatory Bowel Disease (IBD), DNBS-Induced Colitis 553400 Rat 535
Inflammatory Bowel Disease (IBD), DSS-Induced Colitis 553420 Mouse 350
Inflammatory Bowel Disease (IBD), Oxazolone-Induced Colitis 553430 Mouse 350
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553405 Mouse 300
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553410 Rat 535
Pancreatitis, Acute, Caerulein-Induced 566000 Mouse 230
Pruritus (Itch), BAM 8-22-Induced 509870 Mouse 225
Pruritus (Itch), Chloroquine-Induced 509800 Mouse 225
Pruritus (Itch), Compound 48/80-Induced 509820 Mouse 225
Pruritus (Itch), Histamine-Induced 509850 Mouse 225
Pruritus (Itch), Serotonin-Induced 509860 Mouse 225
Pruritus (Itch), SLIGRL-NH2-Induced 509840 Mouse 225
Pruritus (Itch), Substance P-Induced 509810 Mouse 225
Psoriasis, Topical, IL-23-Induced 555600 Mouse 400
Pulmonary, Lipopolysaccharide-Induced Neutrophilia 572100 Mouse 200
Pulmonary, Lipopolysaccharide-Induced Neutrophilia 572110 Rat 260
Septic Shock, Cecal Ligation and Puncture 576680 Mouse 370
Septic Shock, Lipopolysaccharide (without galactosamine) 576710 Mouse 200
Septic Shock, Lipopolysaccharide 576700 Mouse 200
Septic Shock, Lipopolysaccharide 576750 Rat 270
Staphylococcus aureus (Smith, ATCC 19636), Dermal Infection 608070 Mouse 260
Staphylococcus aureus USA300 MRSA (BAA-1556), Dermal Infection 608207 Mouse 270
Staphylococcus aureus USA300 MRSA (BAA-1717), Dermal Infection 608190 Mouse 270
Staphylococcus aureus USA300 MRSA (BAA-1717), Wound Infection, CFU/g 608200 Mouse 320
Wound Healing, Skin 595000 Mouse 265
Wound Healing, Skin, db/db Mouse 595020 Mouse 640