PDS >> Efficacy Models >> Inflammation / Allergy

Inflammation/Allergy In vivo Models for Drug Discovery

 

Pharmacology Discovery Services has over 30 years of experience in developing, and conducting studies with, a diverse set of in vivo models for inflammatory diseases.  These models range from basic models of immune modulation, restoration, suppression and stimulation to specific models of inflammation-induced organ damage.  

Our ability to deliver multi-faceted outcome studies means that you will receive the data that is most appropriate for your drug discovery program.  All experimental models are tested in a dose-dependent manner with approved benchmark positive controls.  We routinely measure relevant biomarkers (e.g., cytokines), physiologic outcomes, like airway hyper responsiveness and swelling.  We also can provide more complex behavioral outcome measures such as scratching or mechanical allodynia or histopathology.    To meet the needs of your specific Inflammation/Allergy drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Validated Inflammation/Allergy In vivo Models

  • Allergic/irritant contact or atopic dermatitis
  • Allergic reaction
  • Collagen (CIA), mAb (CAIA) or adjuvant (AIA) induced arthritis
  • Colitis
  • Models of immune modulation: restoration, suppression or stimulation
  • Psoriasis
  • Pulmonary Inflammation
  • Septic shock (LPS-induced or cecal ligation and puncture)
  • Wound healing
  • Organ specific models of pancreatitis and pulmonary, hepatic or renal fibrosis

In Vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.  

Inflammation / Allergy Models
Model Name Item Number Species
Allergy, Passive Cutaneous Anaphylaxis 503000 Rat
Antitussive Test 508800 Guinea pig
Antitussive Test (Capsaicin) 508850 Guinea pig
Anxiety, Elevated Plus-Maze 508900 Rat
Hepatic Injury, Concanavalin A 546030 Mouse
Hepatic Injury, Acetaminophen (APAP) 546040 Mouse
Hepatic Injury, Chronic Liver Fibrosis 546050 Rat
Hepatotoxicity, ALT 546110 Mouse
Hyperuricemia, Potassium Oxonate Induced 546600 Rat
Histamine H1 Antagonism 547000 Rat
Immune Restoration, Hematopoiesis 550600 Mouse
Inflammation, Adjuvant Arthritis 553010 Rat
Inflammation, Inflammatory Bowel Disease 553400 Rat
Inflammation, Inflammatory Bowel Disease, DSS-induced Colitis 553420 Mouse
Inflammation, Carrageenan 553510 Mouse
Inflammation, Carrageenan 553520 Rat
Inflammation, Collagen Arthritis, mAB 553600 Mouse
Inflammation, Collagen Induced  Arthritis 553700 Rat
Inflammation, Topical, Arachidonic Acid 554010 Mouse
Inflammation, Topical, Capsaicin 554310 Mouse
Inflammation, Topical, Croton Oil 554510 Mouse
Inflammation, Topical, Phorbol Ester 555010 Mouse
Inflammation, Topical, Oxazolone 555510 Mouse
Inflammation, Topical, Psoriasis Induced by IL-23 555600 Mouse
Inflammation, Atopic Dermatitis, DNCB-induced 555700 Mouse
Pancreatitis, Acute 566000 Mouse
Septic Shock, Cecal Ligation and Puncture 576680 Mouse
Septic Shock, Lipopolysaccharide 576700 Mouse
Septic Shock, Lipopolysaccharide (without galactosamine) 576710 Mouse
Septic Shock, Lipopolysaccharide 576750 Rat
Wound Healing, Skin 595000 Mouse
Wound Healing, Skin, db/db Mouse 595020 Mouse