PDS >> Efficacy Models >> Inflammation / Allergy

Inflammation/Allergy In vivo Models for Drug Discovery

IBD White Paper

 

Pharmacology Discovery Services has over 30 years of experience in developing, and conducting studies with, a diverse set of in vivo models for inflammatory diseases.  These models range from basic models of immune modulation, restoration, suppression and stimulation to specific models of inflammation-induced organ damage.

Our ability to deliver multi-faceted outcome studies means that you will receive the data that is most appropriate for your drug discovery program.  All experimental models are tested in a dose-dependent manner with approved benchmark positive controls.  We routinely measure relevant biomarkers (e.g., cytokines), physiologic outcomes, like airway hyper responsiveness and swelling.  We also can provide more complex behavioral outcome measures such as scratching or mechanical allodynia or histopathology.    To meet the needs of your specific Inflammation/Allergy drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Validated Inflammation/Allergy In Vivo Models

  • Allergic/irritant contact or atopic dermatitis
  • Allergic reaction
  • Collagen (CIA), mAb (CAIA) or adjuvant (AIA) induced arthritis
  • Colitis
  • Models of immune modulation: restoration, suppression or stimulation
  • Psoriasis
  • Pulmonary Inflammation
  • Septic shock (LPS-induced or cecal ligation and puncture)
  • Wound healing
  • Organ specific models of pancreatitis and pulmonary, hepatic or renal fibrosis

In Vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.

Publications

 

Auto-Immune Disease*
Model Name Item Number Species Price/Animal ($USD)
Arthritis, Adjuvant-Induced (AIA) 553010 Rat 550
Arthritis, Collagen mAb-Induced (CAIA) 553600 Mouse 650
Arthritis, Collagen-Induced (CIA) 553680 Mouse 550
Arthritis, Collagen-Induced (CIA) 553700 Rat 550
Diabetes, Type I, Streptozotocin-Induced 541000 Mouse 225
Diabetes, Type I, Streptozotocin-Induced 541010 Rat 275

*Other auto-immune disease models include Inflammatory Bowel Disease (found under Digestive System) and Psoriasis (found under Dermal Inflammation).

 

Dermal Inflammation*
Model Name Item Number Species Price/Animal ($USD)
Allergy, Passive Cutaneous Anaphylaxis 503000 Rat 280
Dermatitis, Atopic, DNCB-Induced 555700 Mouse 950
Dermatitis, Contact, Arachidonic Acid-Induced 554010 Mouse 180
Dermatitis, Contact, Capsaicin-Induced 554310 Mouse 180
Dermatitis, Contact, Croton Oil-Induced 554510 Mouse 180
Dermatitis, Contact, Oxazolone-Induced 555510 Mouse 265
Dermatitis, Contact, Phorbol Ester-Induced 555010 Mouse 180
Psoriasis, Topical, IL-23-Induced 555600 Mouse 380
Psoriasis, Topical, Imiquimod (IMQ)-Induced 555650 Mouse 320
Wound Healing, Skin 595000 Mouse 265
Wound Healing, Skin, db/db Mouse 595020 Mouse 640

*Other dermal inflammation disease models include Pruritus (found under CNS/Pain).

 

Digestive System
Model Name Item Number Species Price/Animal ($USD)
Gastric Irritation 535020 Rat 220
Gastric Ulcers, Aspirin-Induced 535900 Rat 220
Gastric Ulcers, Ethanol-Induced 536000 Rat 220
Hepatic Injury, Acetaminophen (APAP)-Induced 546040 Mouse 190
Hepatic Injury, Concanavalin A-Induced 546030 Mouse 190
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCI4) with Phenobarbial-Induced 546050 Rat 560
Hepatic Injury, Liver Fibrosis, Chronic, Carbon Tetrachloride (CCl4)-Induced 546060 Rat 560
Hepatic Injury, Nonalcoholic Steatohepatitis (NASH), MCD Diet-Induced 546080 Mouse 350
Inflammatory Bowel Disease (IBD), DNBS-Induced Colitis 553400 Rat 535
Inflammatory Bowel Disease (IBD), DSS-Induced Colitis 553420 Mouse 350
Inflammatory Bowel Disease (IBD), Oxazolone-Induced Colitis 553430 Mouse 350
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553405 Mouse 300
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553410 Rat 535
Pancreatitis, Acute, Caerulein-Induced 566000 Mouse 230
Pancreatitis, Chronic, Caerulein-Induced 566100 Mouse 350

 

 

Respiratory System
Model Name Item Number Species Price/Animal ($USD)
Asthma, Airway Hyperresponsiveness (AHR), Ovalbumin-Induced 568050 Mouse 590
Cough, Capsaicin-Induced 508850 Guinea pig 420
Cough, Citric Acid-Induced 508800 Guinea pig 450
Fibrosis, Lung, Bleomycin-Induced 568070 Mouse 375
Pulmonary, Lipopolysaccharide-Induced Neutrophilia 572100 Mouse 210
Pulmonary, Lipopolysaccharide-Induced Neutrophilia 572110 Rat 270

 

 

Septic Shock
Model Name Item Number Species Price/Animal ($USD)
Septic Shock, Cecal Ligation and Puncture 576680 Mouse 360
Septic Shock, Lipopolysaccharide (without galactosamine) 576710 Mouse 200
Septic Shock, Lipopolysaccharide 576700 Mouse 200
Septic Shock, Lipopolysaccharide 576750 Rat 270

 

 

Others
Model Name Item Number Species Price/Animal ($USD)
Gout, Hyperuricemia, Potassium Oxonate-Induced 546600 Rat 280
Inflammation, Carrageenan-Induced 553510 Mouse 180
Inflammation, Carrageenan-Induced 553520 Rat 270