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Gastrointestinal In vivo Models for Drug Discovery


Gastrointestinal (GI) disease is characterized by abnormalities in the gastrointestinal tract which includes the esophagus, liver, gallbladder, stomach, pancreas, intestines and colon. Inflammation in these areas can cause a variety of GI diseases or dysfunctions and can be difficult to diagnose. According to the CDC, in the United States alone, inflammatory bowel disease (Crohn's disease or ulcerative colitis) affects over 1 million people.

Pharmacology Discovery Services has conducted in vivo testing for both side-effect profiling and efficacy in GI disease for over 30 years. Our models allow examination of GI motility and colonic function or you may test agents designed to prevent a variety of GI related diseases.  We also employ a broad range of outcome measures to assess GI safety and/or therapeutic efficacy of novel test articles. All models are validated in a dose-dependent manner with approved benchmark positive controls to assure high-quality, reproducible data is provided to our clients.  To meet the needs of your specific gastrointestinal drug discovery project we also have the flexibility and expertise to develop custom in vivo models.

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Gastrointestinal In Vivo Models
Model Name Item Number Species Price/Animal ($USD)
Candida albicans azole resistant (R357), Systemic Infection Kidney CFU/g 609040 Mouse 260
Cholecystokinin, CCK1 (CCKA) Antagonism 517010 Mouse 190
Cholecystokinin, CCK2 (CCKB) Agonism/Antagonism 517510 Rat 220
Emesis, Suncus murinus 530820 Suncus 720
Eschericia coli (ATCC 700336), UTI Model, CFU 608380 Mouse 400
Gastric Acidity, Basal 533000 Rat 225
Gastric Acidity, Pentagastrin 534000 Rat 225
Gastric Acidity, Pylorus Ligation 534100 Rat 260
Gastric Emptying, Test Meal 534550 Rat 260
Gastric Irritation 535020 Rat 220
Gastric Ulcers, Aspirin-Induced 535900 Rat 220
Gastric Ulcers, Ethanol-Induced 536000 Rat 220
Gastrointestinal Motility 537920 Mouse 190
Gastrointestinal Motility 537940 Rat 260
Gastrointestinal Motility, 5-HTP Induced Diarrhea 538200 Mouse 180
Gastrointestinal Motility, Colonic Propulsion, Clonidine 538100 Mouse 220
Gastrointestinal Motility, Colonic Propulsion, Loperamide 538110 Mouse 220
Gastrointestinal Motility, Colonic Propulsion, Morphine 538120 Mouse 220
Gout, Hyperuricemia, Potassium Oxonate-Induced 546600 Rat 280
Inflammatory Bowel Disease (IBD), DNBS-Induced Colitis 553400 Rat 535
Inflammatory Bowel Disease (IBD), DSS-Induced Colitis 553420 Mouse 350
Inflammatory Bowel Disease (IBD), Oxazolone-Induced Colitis 553430 Mouse 350
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553405 Mouse 300
Inflammatory Bowel Disease (IBD), TNBS-Induced Colitis 553410 Rat 535
Renal Function 576000 Rat 250
Renal, Acute Renal Failure, Ischemia/Reperfusion 575000 Rat 770
Renal, Chronic Failure, Remnant Kidney 575500 Rat 900