PDS >> Efficacy Models >> Cardiovascular

Cardiovascular In vivo Models for Drug Discovery

 

Cardiovascular disease (CVD) is one of the leading causes of death for both men and women worldwide. CVDs affect the heart and blood vessels, leading to a variety of conditions including ischemia, stroke, heart attack, angina and cardiomyopathy. Pharmacology Discovery Services has conducted in vivo testing for cardiovascular disease using in vivo models for both side-effect profiling and efficacy for over 30 years.  

We can meet a variety of study endpoints to generate the high-quality, reproducible data your projects require.  All experimental models are tested in a dose-dependent manner with approved benchmark positive controls.  We also have experience running combination studies with standard of care control regimes.  Whether you are trying to evaluate potential cardiovascular liabilities during lead optimization or trying to verify in vivo efficacy, we can provide high quality and reproducible results to progress your drug discovery program.  To meet the needs of your specific Cardiovascular drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Validated Cardiovascular In vivo Models

  • Antagonism of Adrenergic Mediators
  • Arrhythmia
  • Clotting Homeostasis
  • Hypertension
  • Dyslipidemia
  • Thrombosis

Side Effect Profiling

  • Cardiovascular Safety
  • Clinical Chemistry
  • Exposure in Plasma
  • Modified Irwin Testing
  • MTD
  • QTc testing
  • Tolerability

In vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies. 

Cardiovascular In Vivo Models
Model Name Item Number Species
Adenosine A1 Agonism 500300 Rat
Adenosine A1 Antagonism 500610 Rat
Adrenergic alpha1 Antagonism 501010 Mouse
Adrenergic alpha2A Agonism 501500 Rat
Adrenergic alpha2A Antagonism 502010 Rat
Adrenergic beta1 Antagonism 502500 Mouse
Bleeding Time 510200 Rat
Body Temperature 510910 Mouse
Cardiac Arrhythmia, Aconitine (PO) 512010 Mouse
Cardiac Arrhythmia, Aconitine (PO) 512060 Rat
Cardiovascular, Postural Hypotension, Tilt Response 515350 Rat
Cardiovascular, Blood Pressure & Heart Rate (SHR 1, 2, 4 hr) 515000 Rat
Cardiovascular, Blood Pressure & Heart Rate (NTR, 0.5, 1, 2 hrs) 515310 Rat
Cardiovascular, B. P. & Heart Rate, Rat, Safety non-GLP 516000 Rat
Cardiovascular, QTc Interval 516350 Guinea pig
Cardiovascular, Telemetry, Rat 516400 Rat
Convulsions, Maximal Electroshock 523990 Mouse