In vivo Microbiology

 

With the rising prevalence of drug-resistant microorganisms, effective and potent anti-infective agents are becoming increasingly more relevant in order to treat infectious diseases.  The scientific team at Pharmacology Discovery Services works diligently with our clients to provide a robust portfolio of in vivo Anti-infective models to support the discovery and development of novel antimicrobial therapies. 

Our team of Technical and Study Directors have experience in Anti-infective drug development and clinical microbiology.  We can meet a variety of study endpoints to generate the high-quality, reproducible data your projects require including minimal data scatter and dose-response to standard antimicrobial agents.  Our models have been used to test small molecules, drug combinations, biologics, RNAi, liposomal formulations, nanoparticles, and vaccines.  To meet the needs of your specific Anti-infective drug discovery project we also have the flexibility and expertise to develop custom in vivo models.


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Determine In vivo Efficacy with Survival and Tissue Burden Models

We have over 50 validated infection models with clinically relevant pathogens:

  • Ocular, peritonitis, pneumonia or sepsis
  • Skin, thigh muscle, wound or vaginal
  • Models with multi-drug resistant (MDR) bacterial pathogens

Pathogen types include:

  • Fungi: C. albicans, A. fumigatus
  • Gram-negative bacteria: A. baumannii, E. coli, K. pneumoniae, N. gonorrhoeae, P. aeruginosa
  • Gram-positive bacteria: E. faecalis, S. aureus, S. epidermidis, S. pneumoniae, S. pyogenes

Flexible Dosing Routes:

  • ID, IM, IN, IP, IT, IV, PO, RO, SC or topical
  • Continuous IV infusion or dose fractionation

Multiple Readouts Available

  • Survival or microbial counts
  • Counts of resistant microbial variants
  • Histopathology
  • PK exposure
  • Cytokine profile
  • Flow cytometry
  • quantitative RT-PCR

In vivo Pharmacology Expertise

Each of our Technical Directors specializes in selected therapeutic areas so they may provide expert scientific support to our clients.  This involves consulting with clients to identify an appropriate model to meet their scientific objectives, designing studies and writing the custom protocols and statements of work (SOWs) to meet quality assurance guidelines.  They also work closely with our Study Directors to assure that SOWs are clear and that all methods and timelines are feasible.  Our laboratory staff also averages 15 years of experience conducting in vivo pharmacology studies.

Anti-Infective In Vivo Models
Model Name Item Number Species
Aspergillus fumigatus (ATCC 13073), Systemic (IV) Infection, LD90-100 609100 Mouse
Candida albicans (ATCC 10231), Systemic (IV) Infection, LD90-100 609010 Mouse
Candida albicans (ATCC 44858), Systemic (IV) Infection, LD90-100 609020 Mouse
Candida albicans (ATCC 44858), Vulvovaginal Candidiasis 609050 Rat
Candida albicans (R303), Systemic (IV) Infection, Kidney, CFU/g 609035 Mouse
Candida albicans, azole resistant (R357), Systemic Infection, Kidney, CFU/g 609040 Mouse
Candida albicans, azole resistant (R357),Vulvovaginal Infection 609060 Rat
Acinetobacter baumannii (ATCC 17978), Lung Infection Model, CFU/g 608800 Mouse
Acinetobacter baumannii ADC-25 OXA-23 OXA-66 (FDA-CDC AR-BANK#0282) Lung Model 608820 Mouse
Escherichia coli (ATCC 25922), Peritonitis, LD90-100 608310 Mouse
Escherichia coli (ATCC 25922),Thigh Infection Model, CFU/g 608330 Mouse
Escherichia coli (ATCC 700336), Urinary Tract Infection Model, 7 day 608380 Mouse
Escherichia coli MCR-1 ESBL (FDA-CDC AR-BANK#0349) Thigh Infection Model 608335 Mouse
Escherichia coli NDM-1 (FDA-CDC AR-BANK#0055),Thigh Infection Model, CFU/g 608340 Mouse
Klebsiella pneumoniae (ATCC 10031), Peritonitis, LD90-100 608510 Mouse
Klebsiella pneumoniae (ATCC 43816), Lung Infection Model, CFU/g 608550 Mouse
Klebsiella pneumoniae (ATCC 43816), Peritonitis, LD90-100 608540 Mouse
Klebsiella pneumoniae (ATCC 43816), Thigh Infection Model, CFU/g 608570 Mouse
Klebsiella pneumoniae KPC-2, (BAA-1705), Thigh Infection Model, CFU/g 608571 Mouse
Klebsiella pneumoniae NDM-1, (NCTC-13443), Thigh Infection Model, CFU/g 608573 Mouse
Klebsiella pneumoniae NDM-1, (NCTC-13443), Lung Infection Model, CFU/g 608574 Mouse
Neisseria gonorrhoeae (FA1090 ATCC 700825), Vaginal Infection Model 608600 Mouse
Pseudomonas aeruginosa (ATCC 15692), Ocular Infection Model, CFU/g 608690 Mouse
Pseudomonas aeruginosa (ATCC 27853), Lung Infection Model, CFU/g 608640 Mouse
Pseudomonas aeruginosa (ATCC 27853), Peritonitis, LD90-100 608620 Mouse
Pseudomonas aeruginosa (ATCC 27853), Thigh Infection Model, CFU/g 608650 Mouse
Pseudomonas aeruginosa (ATCC 9027), Peritonitis, LD90-100 608610 Mouse
Pseudomonas aeruginosa Carbepenem resistant (LES 431), Lung Infection Model, CFU/g 608645 Mouse
Pseudomonas aeruginosa Carbepenem resistant (LES 431), Peritonitis, LD90-100 608630 Mouse
Pseudomonas aeruginosa Carbepenem resistant (LES 431), Thigh Infection Model, CFU/g 608655 Mouse
Enterococcus faecalis (ATCC 29212), Peritonitis, LD90-100 608220 Mouse
Enterococcus faecalis VRE (ATCC 51575), Peritonitis, LD90-100 608250 Mouse
Enterococcus faecalis VRE (ATCC 51575), Systemic (IV), Kidney CFU/g 608270 Mouse
Staphylococcus aureus (ATCC 29213), Thigh Infection Model, CFU/g 608105 Mouse
Staphylococcus aureus (Smith, ATCC 19636), Peritonitis, LD90-100 608010 Mouse
Staphylococcus aureus (Smith, ATCC 19636), Thigh Infection Model CFU/g 608050 Mouse
Staphylococcus aureus (Smith, ATCC 19636),Dermal Infection 608070 Mouse
Staphylococcus aureus MRSA (ATCC 33591), Lung Infection Model, CFU/g 608125 Mouse
Staphylococcus aureus MRSA (ATCC 33591), Peritonitis, LD90-100 608110 Mouse
Staphylococcus aureus MRSA (ATCC 33591), Thigh Infection Model, CFU/g 608130 Mouse
Staphylococcus aureus MRSA (ATCC 33592), Peritonitis, LD90-100 608140 Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Dermal Infection  608207 Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Peritonitis, LD90-100 608206 Mouse
Staphylococcus aureus USA300 MRSA (BAA-1556), Thigh Infection CFU/g 608208 Mouse
Staphylococcus aureus USA300 MRSA (BAA-1717), Dermal Infection  608190 Mouse
Staphylococcus aureus VRSA (VRS-2), Thigh Infection Model, CFU/g 608180 Mouse
Staphylococcus epidermidis (ATCC 12228), Peritonitis, LD90-100 608150 Mouse
Streptococcus pneumoniae (ATCC 6301), Lung Infection Model, LD90-100 608100 Mouse
Streptococcus pneumoniae (ATCC 6301), Peritonitis, LD90-100 608080 Mouse
Streptococcus pyogenes (ATCC 14289), Peritonitis, LD90-100 608700 Mouse